×

  • 首页
  • 专业版
  • ENGLISH
  • 搜索 搜索
  • 无障碍浏览 无障碍浏览

研究队伍

陈德喜

浏览次数:
字号: + - 14

陈德喜.jpg

    陈德喜,教授,研究员。1997年获得北京大学医学院生物化学与分子生物学博士学位;1997年至2006年先后在美国匹兹堡大学神经研究所、美国波特兰Dow R.S神经生物研究所、和美国俄勒冈健康与科学大学进行衰老和肿瘤学研究;2006年至2013年,任首都医科大学附属北京佑安医院感染中心副主任,性病艾滋病研究室主任,2010年至今任北京市肝病研究所常务副所长。

    自2006年底作为首都医科大学引进人才回国任北京佑安医院的艾滋病实验室主任,创建并完善了集艾滋病临床检验与科研于一体的包括细胞生物学、免疫学和分子生物学研究的现代化实验室。为北京市大课题、国家“十一五”和“十二五”、国家自然基金和北京市自然基金的完成及人才培养提供了保障,并获得了艾滋病北京市重点实验室。依据这一平台,艾滋病中心在5年间发表SCI收录论著 50余篇,培养博士研究生10名,硕士研究生15名,申请到“十一五”和“十二五”、“十三五”和国家自然基金等科研基金共20余项,基金总额近5千余万元。

    任北京市肝病研究所常务副所长以来,在院领导和北京市卫计委的支持下带领研究所全体人员利用5年时间初步建成了与时代相适应的现代化肝病研究所。建立起了包括小动物研究平台;蛋白质组学临床肝病转化研究平台;核酸检测实验平台;质谱流式平台,细胞生物学研究平台;组织形态研究平台在内的6大科研平台. 6大研究平台的建立和完善,为我们的转化医学研究提供了很好的保障.6年来选派了7名博士后去美国学习一年,一名访问学者赴日本培训两年,并每年邀请国内外学者来所讲学10余次。20125月,我们在北京组织并主持召开了高水平的中美肝癌诊断研究国际论坛。全所近5年发表SCI论著40余篇,总影响因子超过100分。申报和获批发明专利各8项。获得了国家自然基金13项和北京市人才发展相关基金9项。完成了12项市局级以上课题的基础上利用首医大基础与临床合作基金和佑安肝病基金的资助开展了以重肝临床发病机制研究和原发性肝癌细胞治疗机制研究为重点的自主立项课题30个。申报和获批了北京市肝炎与肝癌精准医疗及转化工程技术研究中心。

    带领科研团队紧紧围绕我国艾滋病脑痴呆的诊断治疗分子机制、抗病药物引起线粒体毒性副作用的机制研究以及HIVHBV耐药(表型耐药、基因型耐药、病毒载量等)新型检测方法展开了创新性研究。针对艾滋病脑病这一科学热点,同时在我国也是空白点,带领科研团队建立从临床患者、动物模型到体外神经细胞培养全方位的研究平台。构建HIV/gp120转基因小鼠,引进了p53ASPP2基因缺失小鼠,进行脑痴呆分子机制分析,该部分我们共获得国家自然基金3项,国家自然基金国际合作1项,北京市自然基金重点项目1项,都顺利完成课题结题,其中1项国家自然基金结题获得了优秀,申请专利1项。针对抗病毒治疗的线粒体毒性,在“十一五”重大专项的支持下建立线粒体DNA定量检测方法,研究NRTI线粒体毒性机制,为艾滋病临床诊疗、提高药物安全性提供重要参考,此部分获得授权专利2项。同时在“十一五和十二五”重大专项支持下构建标准的新型HIV/HBV表型耐药分析载体体系,我国艾滋病脑病和耐药机制研究做出突出贡献。

    回国后作为课题负责人先后申请到科研项目近20项,发表SCI收录文章70余篇,包括hepatologyCancer Research等知名杂志,总影响因子超过300余分,他引次数超过2500余次,中文核心期刊论著近200余篇,申请专利7项,其中授权专利5项,先后获得2012年北京市科技进步三等奖、2011年中华医学科技奖二等奖、2010年度丰台区科学技术二等奖、2009年度北京市卫生系统“十百千”卫生人才“十”层次人选以及第四届北京市归国人员创新创业特别贡献奖等奖励和政府特殊津贴人才。

专业组织会员

神经科学学会  1998-现在

美国癌症研究协会 2003-现在

代表性论著

Liu K, Zang Y, Guo X, Wei F, Yin J, Pang L, Chen D. The Δ133p53 Isoform Reduces Wtp53-induced Stimulation of DNA Pol γ Activity in the Presence and Absence of D4T. Aging Dis. 2017 Apr 1;8(2):228-239.

Liu Z, Qiao L, Zhang Y, Zang Y, Shi Y, Liu K, Zhang X, Lu X, Yuan L, Su B,Zhang T, Wu H, Chen D. ASPP2 Plays a Dual Role in gp120-Induced Autophagy and Apoptosis of Neuroblastoma Cells. Front Neurosci. 2017 Mar 24;11:150

Liu K, Lin D, Ouyang Y, Pang L, Guo X, Wang S, Zang Y, Chen D. Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression-induced apoptosis in hepatoma cells. Tumour Biol. 2017 Mar;39(3):1010428317695026.

Wang SS, Chen YH, Chen N, Wang LJ, Chen DX, Weng HL, Dooley S, Ding HG. Hydrogen sulfide promotes autophagy of hepatocellular carcinoma cells through the PI3K/Akt/mTOR signaling pathway. Cell Death Dis. 2017 Mar 23;8(3):e2688.

Gao Z, Shan J, Wang B, Qiao L, Chen D, Zhang Y. DRAM Is Involved in Regulating Nucleoside Analog-Induced Neuronal Autophagy in a p53-Independent Manner. Mol Neurobiol. 2017 Mar 6. doi: 10.1007/s12035-017-0426-5. [Epub ahead of print

Liu K, Hao M, Ouyang Y, Zheng J, Chen D. CD133(+) cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma. Sci Rep. 2017 Jan 30;7:41499

Shi H, Han W, Shi H, Ren F, Chen D, Chen Y, Duan Z. Augmenter of liver regeneration protects against carbon tetrachloride-induced liver injury by promoting autophagy in mice. Oncotarget. 2017 Feb 21;8(8):12637-12648.

Zang Y, Shi Y, Liu K, Qiao L, Guo X, Chen D. Δ40p53 is involved in the inactivation of autophagy and contributes to inhibition of cell death in HCT116-Δ40p53 cells. Oncotarget. 2017 Feb 21;8(8):12754-12763.

Van Hook K, Wang Z, Chen D, Nold C, Zhu Z, Anur P, Lee HJ, Yu Z, Sheppard B,Dai MS, Sears R, Spellman P, Lopez CD. ΔN-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1271-1277.

Zhang X, Ding J, Gou C, Wen T, Li L, Wang X, Yang H, Liu D, Lou J, Chen D, Ren F, Li X. Qingchangligan formula attenuates the inflammatory response to protect the liver from acute failure induced by d-galactosamine/lipopolysaccharide in mice. J Ethnopharmacol. 2017 Apr 6;201:108-116

Shi H, Shi H, Ren F, Chen D, Chen Y, Duan Z. Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti-fibrosis effect by inhibition of mammalian target of rapamycin. J Cell Mol Med. 2017Mar;21(3):500-509.

Lin Yuan1, #, Feili Wei2, #, Xin Zhang1, Xianghua Guo2, Xiaofan Lu1, Bin Su1, Tong Zhang1, Hao Wu1,*, Dexi Chen2,3,*. Intercellular Adhesion Molecular-5 as Marker in HIV Associated Neurocognitive Disorder. Aging and disease,Volume 8, Number 3; xxx-xx, June 2017. http://dx.doi.org/10.14336/AD.2016.0918

Yabo Ouyang a,b,1, Luxin Qiao a,b,1, Kai Liu a,b, Yunjin Zang a, Yu Sun a, Yaowu Dong d,Daojie Liu a,b, Xianghua Guo a,b, Feili Wei a,b, Minghua Lin a,b, Fujie Zhang c, ** ,Dexi Chen a,b,*. Mitochondrial DNA mutations in blood samples from HIV-1-infected children undergoing long-term antiretroviral therapy. Mutation  Research. 805 (2016) 1–6

Xiuhong Liu1,2,*, Shuang Wang1,2,*, Xianghua Guo1, Feili Wei1, Jiming Yin1, Yunjin Zang2, Ning Li2, Dexi Chen1,2  Exogenous p53 and ASPP2 expression enhances rAdV-TK/ GCV-induced death in hepatocellular carcinoma cells lacking functional p53. Oncotarget, Advance Publications 2016

Ying Shi, JunweiWang , YuheWang , AnnaWang ,Hongliang Guo, FeiliWei,Sanjay R. Mehta,Stephen Espitia , Davey M. Smith , Longgen Liu f, Yulin Zhang ,Dexi Chen.A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines. Cancer letters 371 (2016) 285–291

Zhang X, Ding J, Gou C, Wen T, Li L, Wang X, Yang H, Liu D, Lou J, Chen D, Ren F, Li X.Qingchangligan Formula Attenuates the Inflammatory Response to Protect the Liver from Acute Failure Induced by D-galactosamine/ Lipopolysaccharide in Mice. J Ethnopharmacol. 2016 Nov 7. pii: S0378-8741(16)31734-2. doi: 10.1016/j.jep.2016.11.007. [Epub ahead of print]

Shi H, Shi H, Ren F, Chen D, Chen Y, Duan Z.Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti-fibrosis effect by inhibition of mammalian target of rapamycin. J Cell Mol Med. 2016 Sep 30. doi: 10.1111/jcmm.12994. [Epub ahead of print]

Jia Z, Huang X, Wu H, Zhang T, Li N, Ding P, Sun Y, Liu Z, Wei F, Zhang H, Jiao Y, Ji Y, Zhang Y, Guo C, Li W, Mou D, Xia W, Li Z, Chen D, Yan H, Chen X, Zhao J, Meyers K, Cohen T, Mayer K, Salomon JA, Lu Z, Dye C.HIV burden in men who have sex with men: a prospective cohort study 2007-2012. Sci Rep. 2015 Jul 2;5:11205. doi: 10.1038/srep11205.

Ji-ming Yin, Li-bo Sun, Jia-sheng Zheng, Xin-xin Wang, De-xi Chen, Ning Li . Inflammation Research, 2016,65(12):1009-1020.Copper chelation by trientine dihydrochloride inhibits liver RFA-induced inflammatory responses in vivo. 

Y.-L.Zhang1, Y.-B.OuYang1, L.-G. Liu2, D.-X. Chen1. Blood-brain barrier and neuro-AIDS  European Review for Medical and Pharmacological Sciences, 2015; 19: 4927-4939.

Ouyang Y#, Liu K#, Hao M, Zheng R, Zhang C, Wu Y, Zhang X, Li N, Zheng J, Chen D. Radiofrequency ablation-increased CXCL10 is associated with earlier recurrence of hepatocellular carcinoma by promoting stemness[J]. Tumour Biology, 2015. 2015 Oct 13. [Epub ahead of print]

Feng R, Li Z, Xiangying Z, Hongbo S, Tao W, Li B, Sujun Z, Yu C, Dexi C, Liying L, Zhongping D*. Inhibition of glycogen synthase kinase3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptorα. Cell Death & Disease, 2016, accepted.

F Ren#, H Shi#, L Zhang, X Zhang, T Wen, B Xie, S Zheng, Y Chen, L Li, D Chen, Z Duan*. The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B.Journal of Viral Hepatitis, 2016, 23: 23-31.

Liu K#, Jiang T#, Ouyang Y, Shi Y, Zang Y, Li N, Lu S, Chen D. Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma[J]. Oncotarget, 2015,6(18):16507-16516.

Zhang Y, Wang B, Liang Q, Qiao L, Xu B, Zhang H, Yang S, Chen J, Guo H, Wu J, Chen D. Mitochondrial DNA D-loop AG/TC transition mutation in cortical neurons of mice after long-term exposure to nucleoside analogues.J Neurovirol. 2015 Oct;21(5):500-7. 

Liu Z, Li W, Xu M, Sheng B, Yang Z, Jiao Y, Zhang T, Mou D, Chen D, Wu H. Development of an In-House Multiplex Nested RT-PCR Method for Detecting Acute HIV-1 Infection in High Risk Populations.Curr HIV Res. 2015;13(4):315-24.

Yuan L, Liu A, Qiao L, Sheng B, Xu M, Li W, Chen D. The relationship of CSF and plasma cytokine levels in HIV infected patients with neurocognitive impairment.Biomed Res Int. 2015;2015:506872. 

Shi HB, Sun HQ, Shi HL, Ren F, Chen Y, Chen DX, Lou JL, Duan ZP. Autophagy in anti-apoptotic effect of augmenter of liver regeneration in HepG2 cells.World J Gastroenterol. 2015; 21(17): 5250-5258.

Liu YMShi HBLiu YRShi HLRen FChen YChen DXLou JLDuan ZP. Protective effect of Ganshuang Granules on liver cirrhosis by suppressing regulatory T cells in a mouse model. Chin J Integr Med.K Liu, Y Shi, X Guo, S Wang, Y Ouyang, M Hao, D Liu, L Qiao, N Li, J Zheng, D Chen CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2 Cell Death and Disease (2014) 5, e1323

Shi Y, Han Y, Xie F, Wang A, Feng X, Li N, Guo H, Chen D . ASPP2 enhances Oxaliplatin (L-OHP)-induced colorectal cancer cell apoptosis in a p53-independent manner by inhibiting cell autophagy.J Cell Mol Med. 2014. doi: 10.1111/jcmm.12435. [Epub ahead of print]PMID:25534115

Xie F, Jia L, Lin M, Shi Y, Yin J, Liu Y, Chen D*, Meng Q.ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease.J Cell Mol Med. 2014 Sep 25. doi: 10.1111/jcmm.12364. [Epub ahead of print]PMID:25256142 

Li Z, Jiao Y, Hu Y, Cui L, Chen D, Wu H, Zhang J, He W.Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection.Cell MolImmunol. 2014 Sep 15. doi: 10.1038/cmi.2014.77. [Epub ahead of print]PMID:25220734

Li Z, Li W, Li N, Jiao Y, Chen D, Cui L, Hu Y, Wu H, He W. γδ T cells are involved in acute HIV infection and associated with AIDS progression.PLoS One. 2014 Sep 4;9(9):e106064. doi: 10.1371/journal.pone.0106064. eCollection 2014.PMID:25188438

Zhu R, Chen D, Lin D, Lu F, Yin J, Li N. Adenovirus vector-mediated herpes simplex virus-thymidine kinase gene/ganciclovir system exhibits anti-tumor effects in an orthotopic hepatocellular carcinoma model.Pharmazie. 2014 Jul;69(7):547-52.PMID:25073402

Jiao Y, Song J, Sun X, Zhu W, Wang R, Zhang Y, Li W, Zhang T, Chen D, Wu H. Higher HIV DNA in CD4+ naïve T-cells during acute HIV-1 infection in rapid progressors.Viral Immunol. 2014 Aug;27(6):316-8. doi: 10.1089/vim.2014.0037. Epub 2014 Jun 3.PMID:24892927

Ouyang Y, Liu L, Zhang Y, Yuan L, Liu Z, Yang S, Wei F, Qiao L, Chen D.Discordant patterns of tissue-specific genetic characteristics in the HIV-1 env gene from HIV-associated neurocognitive disorder (HAND) and non-HAND patients.J Neurovirol. 2014 Aug;20(4):332-40. doi: 10.1007/s13365-014-0247-5. Epub 2014 Apr 23.PMID:24756883

Wu G, Zhu W, Gao Y, Li Y, Chen D, Duan Z, Wang Q, Xiao J The risk factors of hand-foot-mouth disease in chinese mainland people..Indian J Pediatr. 2014 Dec;81(12):1405-6. doi: 10.1007/s12098-014-1420-9. Epub 2014 Apr 5. No abstract available.PMID:24705937

Zhang Y, Song F, Gao Z, Ding W, Qiao L, Yang S, Chen X, Jin R, Chen D. Long-term exposure of mice to nucleoside analogues disrupts mitochondrial DNA maintenance in cortical neurons.PLoS One. 2014 Jan 20;9(1):e85637. doi: 10.1371/journal.pone.0085637. eCollection 2014.PMID:24465628 

Liu K, Shi Y, Guo XH, Ouyang YB, Wang SS, Liu DJ, Wang AN, Li N, Chen DX. Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria. Cell Death Dis. 2014 Feb 20; 5:e1078.

Liu K, Shi Y, Guo X, Wang S, Ouyang Y, Hao M, Liu D, Qiao L, Li N, Zheng J, Chen D. CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2.Cell Death Dis. 2014 Jul 17; 5:e1323.

Wen Z, Liu Y, Li F, Ren F, Chen D, Li X, Wen T. Circulating histones exacerbate inflammation in mice with acute liver failure. J Cell Biochem. 2013. doi: 10.1002/jcb.24588. [Epub ahead of print]

Liu K, Sun Y, Liu D, Yin J, Qiao L, Shi Y, Dong Y, Li N, Zhang F, Chen D.Mitochondrial toxicity studied with the PBMC of children from the Chinese national pediatric highly active antiretroviral therapy cohort. PLoS One. 2013;8(2):e57223. doi: 10.1371/journal.pone.0057223.

Yuan L, Qiao L, Wei F, Yin J, Liu L, Ji Y, Smith D, Li N, Chen D.Cytokines in CSF correlate with HIV-associated neurocognitive disorders in the post-HAART era in China. J Neurovirol. 2013;19(2):144-9. doi: 10.1007/s13365-013-0150-5.

Liu L, Zhang Y, Wei F, Zhao Q, Wang X, Yuan L, Li N, Chen D.Discordant genotypic resistance and HIV-1 genetic diversity from paired plasma and cerebrospinal fluid samples in Chinese settings. J Neurovirol. 2013;19(2):131-6. doi: 10.1007/s13365-013-0148-z. Epub 2013.

Kai Liu, Dexi Chen, et al. ASPP2 promotes DRAM-mediated autophagic apoptosis in HCC cells with different p53 status. Liver international. (2013 accept)

Yulin Zhang, Feili Wei, Qi Liang, Wei Ding, Luxin Qiao, Fengli Song, Lifeng Liu, Sufang Yang, Ronghua Jin, Jianhua Gu, Ning Li, Dexi Chen. High levels of divergent HIV-1 quasispecies in patients with neurological opportunistic infections in China. J Neurovirol, 2013. Volume 19, Issue 4, pp 359-366

Ying ShiYulin Zhang Qing Li Ning Li, Dexi Chen. Mutations in the major hydrophilic region (MHR) of Hepatitis B virus genotype C in North China. Journal of medical virology. 12/2012; 84(12):1901-6.

Li Li1,2#, Ronghua Jin2#, Xiaoli Zhang3, Fudong Lv 2, Lifeng Liu 1, Daojie Liu1, Kai Liu1, Ning Li2*, Dexi Chen1,2*. Oncogenic activation of GPC3 by c-Myc in human hepatocellular carcinoma. Hepatology, 2012, 56(4):1380-90

Zhang Y, Wang M, Ding W, Wei F, Zhao Q, Wang X, Shi Y, Li N, Chen D. Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders. Brain Res. 2012  

Liu Z, Li L, Chen Z, Xu M, Zhang T, Jiao Y, Sheng B, Chen D*, Wu H*. Prevalence of GB virus type C viraemia in MSM with or without HIV-1 infection in Beijing, China.  Epidemiol Infect. 2012 Mar 26:1-11.

Zhang Y, Qiao L, Ding W, Wei F, Zhao Q, Wang X, Shi Y, Li N, Smith D, Chen D. An initial screening for HIV-associated neurocognitive disorders of HIV-1 infected patients in China.J Neurovirol. Volume 18, Issue 2 (2012), Page 120-126

Yulin Zhang, Ying Shi, Luxin Qiao, Dexi Chen. Sigma-1 receptor agonists provide neuroprotection against gp120 via a change in bcl-2 expression in mouse neuronal cultures . Brain Res. 2012 Jan 11;1431:13-22.

Yang X, Jiao YM, Wang R, Ji YX, Zhang HW, Zhang YH, Chen DX, Zhang T, Wu H. High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progression. PLoS One. 2012;7(11):e49526.

Hua W, Jiao Y, Zhang H, Zhang T, Chen D, Zhang Y, Chen X, Wu H. Central memory CD4 cells are an early indicator of immune reconstitution in HIV/AIDS patients with anti-retroviral treatment. Immunol Invest. 2012;41(1):1-14..

Jiao Y, Song Y, Kou B, Wang R, Liu Z, Huang X, Chen D, Zhang T, Wu H. Primary CXCR4 co-receptor use in acute HIV infection leads to rapid disease progression in the AE subtype. Viral Immunol. 2012 Aug;25(4):262-7.

Lifeng Liu, Qingxia Zhao, Feili Wei, Ning LiYingShi Dexi Chen* . Genetic Analysis of HIV Type 1 env Gene in Cerebrospinal Fluid and Plasma of Infected Chinese Paid Blood Donors.  AIDS Research and Human Retroviruses AIDS Res Hum Retroviruses. 2011 Jul 19. [Epub ahead of print]

Daijun Xiang, Qing Xia, Dexi Chen, Feng Xia, Yan Zhao, Ning Li, Huiping Yan. Detection of autoantibodies to D-3-phosphoglycerate dehydrogenase in patients with chronic liver disorders and analysis of their clinical relevance. Hepatology research.  2011 Jun 28. [Epub ahead of print]

Xiaoli Zhang , Amy Farrell, Colin Daniel, Hugh Arnold, Charles Scanlan, Bryan Laraway , Mahnaz Janghorban , Lawrence Lum , Dexi Chen , Megan Troxell , Rosalie Sears . Mechanistic insight into c-Myc stabilization in breast cancer involving aberrant Axin1 expression. Proc Natl Acad Sci U S A. 2012,109(8)2790

Jin R, Sun Y, Qi X, Zhang H, Zhang Y, Li N, Ding W, Chen D  E2F1 is Involved in DNA Single-strand Break Repair through Upregulation of Cell-cycle-dependent XRCC1 Expression. DNA repair DNA Repair (Amst). 2011 Jul 12. [Epub ahead of print]

Feili Wei#, Xicheng Wang#, Lifeng Liu, Rong GaoLuxin Qiao, YingShi Dexi Chen* Characterization of HIV Type 1 env Gene in Cerebrospinal Fluid and Blood of Infected Chinese Patients AIDS Research and Human Retroviruses 2011

Zhang H, Zang Y, Sun Y, Jin R, Wu H, Wang M, Li N, Chen D#. A new approach utilizing real-time qPCR to detect in vitro base excision repair. DNA repair, 2010; 9(8):898-906.

Shi Y, Sun S, Liu Y, Li J, Zhang T, Wu H, Chen X, Chen D*, Zhou Y*. Keratin 18 phosphorylation as a progression marker of chronic hepatitis B. Virol J. 2010 Mar 24;7:70

Kampa, K.M.1,2, Acoba, J.D.2, Chen, D.2, Gay, J.2, Lee, H-J.2, Beemer, K.2, Padiernos, E.2, Boonmark, N.3, Zhu, Z.2, Fan, A.C.3,Baily, A.2, Flemming, W.H.2, Corless, C.2, Felsher, D.W.3, Naumovski, L.3,# and Lopez, C.D.2  Apoptosis Stimulating Protein of p53 (ASPP2) Heterozygous Mice Are Tumor Prone and Have Attenuated Cellular Damage-Response Thresholds. PNAS 2009 106(11):4390-5

Huang Chun#, Wu Hao#, Zhang Honghai, Li Ning, Wu Yasong, Dexi Chen*. CCl3L1 preventing gp120-induced neuron death via CREB cell signal pathway.. Brain Research  2009 1257:75-88..

Wu Yasong*, Li Ning, * Zhang Tong, Wu Hao, Huang Chun, Chen Dexi#. Mitochondrial DNA base excision repair and mitochondrial DNA mutation in human hepatic HuH-7 cells exposed to stavudine. Mutation Research 2009 12;664(1-2):28-38

Dexi Chen, Zhiyong Yu, Zhiyi Zhu, Lopez CD.  E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair.. JBC 2008, 283 (22), 15381-9.

*Li N, Wu H, Yang S, Chen D.  Ischemic preconditioning induces XRCC1, DNA polymerase-beta, and DNA ligase III and correlates with enhanced base excision repair. DNA Repair, 2007, 6:1297-1306.

Dexi Chen , Zhiyi Zhu, Zhiyong Yu, Charles D. Lopez . An intact p53 pathway is required for efficient mitochondrial BER.  Cancer Research.  2006,66(&):3485-3494.

Zhiyi Zhu, Jason Ramos,  Kerstin Kampa, Zhiyong Yu, Dexi chen, Charles Lopez. ASPP2 Apoptotic is Modulated by Proteasomal Degradation. J. Biol. Chem. 2005 288(41): 34473-88.

Chen D, Padiernos E, Ding F, Lossos IS, Lopez CD. Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene.Cell Death Differ. 2005 Apr;12(4):358-68

Meller R, Minami M, Cameron J, Chen D, Lan J, HenshaLL D, SIMON R. CREB-mediated Bcl-2 protein expression following ischemic preconditioning. 2005 Feb;25(2):234-46.

Dexi Chen, Manabu Minami, David C. Henshall; Roger P. Simon. Preconditioning Ischemia Enhances Base-Excision Repair Capability within Rat Brain Mitochondrial DNA. J Cereb Blood Flow Metab. 2003 Jan;23(1):88-98.

Dexi Chen‡, Kunlin Jin*, Kenji Kawaguchi†, Masaki Nakayama†, Xiaoman Zhou‡, Zhigang Xiong‡, An Zhou‡, David A. Greenberg*, Steven H. Graham†, and Roger P. Simon‡. Ero1-L, an Ischemia-Inducible Gene from Rat Brain with Homology to Global Ischemia-Induced Gene 11 (Giig11), is Localized to Neuronal Dendrites by a Dispersed Identifier (ID)Element-Dependent Mechanism.  J Neurochem. 2003 May;85(3):670-9

Dexi Chen, Guodong Cao, Cristine O’Horo, Wei Pei and Jun Chen. DNA Base-Excision Repair Activity for Oxidative Lesions in Rat Brain Mitochondria: Marked Age-dependent Regulation. J Neurochem  2002 81 1273-1284.

K. Jin1, X.O. Mao1, M.C. Eshoo1, G. del Rio1, R. Rao1 , D. Chen2, R.P. Simon2 and D.A. Greenberg.1cDNA Microarray Analysis of Changes in Gene Expression Induced by Neuronal Hypoxia In Vitro. Neurochem Res. 2002 Oct;27(10):1105-12.

Xiangping Chu; J. Jefferson;  M. Johnson; L. Root; X. Zhu.; Dexi Chen; R. Simon; Z. Xiong. PC12 cells contain a singtle population of functional protein-gated channels-homomultimeric asic1A. J Neuroph  2002, 87 2555-256.

Martha B. Johnson, Manabu Minami, Dexi Chen, Roger P. Simon. Global ischemia induces expression of Asic2 in rat brain. J Cereb Blood Flow Metab. 2001, 21:734-740

Li YY, Chen D, Watkins SC, Feldman AM..Mitochondrial Abnormalities in Tumor Necrosis Factor-alpha-Induced Heart Failure Are Associated With Impaired DNA Repair Activity. Circulation. 2001 Nov 13;104(20):2492-7

Cao G, Minami M, Pei W, Yan C, Chen D, O'Horo C, Graham SH, Chen J. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death.
J Cereb Blood Flow Metab. 2001 Apr;21(4):321-33.

Chen D, Stetler RA, Cao GD, Pei W, Yin X-M, Chen J. Characterization of the rat DFF35/ICADs: the endogenous inhibitor of DNA fragmentation in neuronal apoptosis. J Biol Chem. 2000 Dec 8;275(49):38508-17.

Chen D, Jing Lan, Wei Pei, Jun Chen. Detection of DNA Base-Excision repair activity for oxidative lesions in adult rat brain mitochondria. J Neurosci Res 2000. 61(2):225-236.

Yan C, Chen J, Chen D, Minami M, Pei W, Yin XM, Simon RP.  Overexpression of the cell death suppressor Bcl-w in ischemic brain: implications for a neuroprotective role via the mitochondrial pathway. J Cereb Blood Flow Metab 2000 Mar;20(3):620-30.

Nagayama T, Lan J, Henshall DC, Chen D, O'Horo C, Simon RP, Chen J.Induction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemiaJ Neurochem 2000 Oct;75(4):1716-28

Nagayama T, Simon RP, Chen D, Henshall DC, Pei W, Stetler RA, Chen J .Activation of poly(ADP-ribose) polymerase in the rat hippocampus may contribute to cellular recovery follow